作者
Jayda N Esplund, Alex D Taylor, Tyler J Stone, Elizabeth L Palavecino, Abdullah Kilic, Vera P Luther, Christopher A Ohl, James R Beardsley
发表日期
2023/1
期刊
Antimicrobial Stewardship & Healthcare Epidemiology
卷号
3
期号
1
页码范围
e5
简介
Objective
To evaluate the clinical impact of the BioFire FilmArray Pneumonia Panel (PNA panel) in critically ill patients.
Design
Single-center, preintervention and postintervention retrospective cohort study.
Setting
Tertiary-care academic medical center.
Patients
Adult ICU patients.
Methods
Patients with quantitative bacterial cultures obtained by bronchoalveolar lavage or tracheal aspirate either before (January–March 2021, preintervention period) or after (January–March 2022, postintervention period) implementation of the PNA panel were randomly screened until 25 patients per study month (75 in each cohort) who met the study criteria were included. Antibiotic use from the day of culture collection through day 5 was compared.
Results
The primary outcome of median time to first antibiotic change based on microbiologic data was 50 hours before the intervention versus 21 hours after the intervention (P = .0006). Also …
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JN Esplund, AD Taylor, TJ Stone, EL Palavecino… - Antimicrobial Stewardship & Healthcare Epidemiology, 2023