作者
Alexander B Remsik, Leroy Williams Jr, Klevest Gjini, Keith Dodd, Jaclyn Thoma, Tyler Jacobson, Matt Walczak, Matthew McMillan, Shruti Rajan, Brittany M Young, Zack Nigogosyan, Hemali Advani, Rosaleena Mohanty, Neelima Tellapragada, Janerra Allen, Mohsen Mazrooyisebdani, Leo M Walton, Peter LE Van Kan, Theresa J Kang, Justin A Sattin, Veena A Nair, Dorothy Farrar Edwards, Justin C Williams, Vivek Prabhakaran
发表日期
2019/3/6
期刊
Frontiers in Neuroscience
卷号
13
页码范围
53
出版商
Frontiers Media SA
简介
Loss of motor function is a common deficit following stroke insult and often manifests as persistent upper extremity (UE) disability which can affect a survivor’s ability to participate in activities of daily living. Recent research suggests the use of brain–computer interface (BCI) devices might improve UE function in stroke survivors at various times since stroke. This randomized crossover-controlled trial examines whether intervention with this BCI device design attenuates the effects of hemiparesis, encourages reorganization of motor related brain signals (EEG measured sensorimotor rhythm desynchronization), and improves movement, as measured by the Action Research Arm Test (ARAT). A sample of 21 stroke survivors, presenting with varied times since stroke and levels of UE impairment, received a maximum of 18–30 h of intervention with a novel electroencephalogram-based BCI-driven functional electrical stimulator (EEG-BCI-FES) device. Driven by spectral power recordings from contralateral EEG electrodes during cued attempted grasping of the hand, the user’s input to the EEG-BCI-FES device modulates horizontal movement of a virtual cursor and also facilitates concurrent stimulation of the impaired UE. Outcome measures of function and capacity were assessed at baseline, mid-therapy, and at completion of therapy while EEG was recorded only during intervention sessions. A significant increase in r-squared values [reflecting Mu rhythm (8–12 Hz) desynchronization as the result of attempted movements of the impaired hand] presented post-therapy compared to baseline. These findings suggest that intervention corresponds with …
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AB Remsik, L Williams Jr, K Gjini, K Dodd, J Thoma… - Frontiers in Neuroscience, 2019