作者
Diana W Bianchi, JL Simpson, LG Jackson, S Elias, W Holzgreve, MI Evans, KA Dukes, LM Sullivan, KW Klinger, FZ Bischoff, S Hahn, KL Johnson, D Lewis, RJ Wapner, F de la Cruz
发表日期
2002/7
期刊
Prenatal Diagnosis: Published in Affiliation With the International Society for Prenatal Diagnosis
卷号
22
期号
7
页码范围
609-615
出版商
John Wiley & Sons, Ltd.
简介
Objectives
The National Institute of Child Health and Human Development Fetal Cell Isolation Study (NIFTY) is a prospective, multicenter clinical project to develop non‐invasive methods of prenatal diagnosis. The initial objective was to assess the utility of fetal cells in the peripheral blood of pregnant women to diagnose or screen for fetal chromosome abnormalities.
Methods
Results of fluorescence in situ hybridization (FISH) analysis on interphase nuclei of fetal cells recovered from maternal blood were compared to metaphase karyotypes of fetal cells obtained by amniocentesis or chorionic villus sampling (CVS). After the first 5 years of the study we performed a planned analysis of the data. We report here the data from 2744 fully processed pre‐procedural blood samples; 1292 samples were from women carrying singleton male fetuses.
Results
Target cell recovery and fetal cell detection were better using …
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