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While information technology (IT) has grown rapidly in enterprises, scholars have emphasized the importance of IT factors and aspects, while limited attention has been paid to the barriers and challenges facing the adoption of IT. In light of this, we stress the importance of barriers inhibiting IT adoption within Small and Medium Enterprises (SME). For this purpose, this paper aims to create a systematic literature review in order to provide a better understanding of barriers to IT adoption within SME. On the basis of 132 selected studies, we identify 18 barriers categorized according to internal and external parameters. Finally, we underline a synthesis and avenues for future research, and provide scientific and managerial implications and guidance for the adoption of IT in SME.