作者
Thomas P Lodise Jr, Susan L Rosenkranz, Matthew Finnemeyer, Scott Evans, Matthew Sims, Marcus J Zervos, C Buddy Creech, Pratish C Patel, Michael Keefer, Paul Riska, Fernanda P Silveira, Marc Scheetz, Richard G Wunderink, Martin Rodriguez, John Schrank, Susan C Bleasdale, Sara Schultz, Michelle Barron, Ann Stapleton, Dannah Wray, Henry Chambers, Vance G Fowler Jr, Thomas L Holland
发表日期
2020/4/10
期刊
Clinical infectious diseases
卷号
70
期号
8
页码范围
1536-1545
出版商
Oxford University Press
简介
Background
Vancomycin is the most commonly administered antibiotic in hospitalized patients, but optimal exposure targets remain controversial. To clarify the therapeutic exposure range, this study evaluated the association between vancomycin exposure and outcomes in patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia.
Methods
This was a prospective, multicenter (n = 14), observational study of 265 hospitalized adults with MRSA bacteremia treated with vancomycin. The primary outcome was treatment failure (TF), defined as 30-day mortality or persistent bacteremia ≥7 days. Secondary outcomes included acute kidney injury (AKI). The study was powered to compare TF between patients who achieved or did not achieve day 2 area under the curve to minimum inhibitory concentration (AUC/MIC) thresholds previously found to be associated with …
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TP Lodise Jr, SL Rosenkranz, M Finnemeyer, S Evans… - Clinical infectious diseases, 2020