作者
Maurizio S Tonetti, Thomas E Van Dyke, working group 1 of the joint EFP/AAP workshop*
发表日期
2013/4
期刊
Journal of periodontology
卷号
84
页码范围
S24-S29
出版商
American Academy of Periodontology
简介
Background: This consensus report is concerned with the association between periodontitis and atherosclerotic cardiovascular disease (ACVD). Periodontitis is a chronic multifactorial inflammatory disease caused by microorganisms and characterized by progressive destruction of the tooth supporting apparatus leading to tooth loss; as such, it is a major public health issue.
Aims: This report examined biological plausibility, epidemiology and early results from intervention trials.
Plausibility: Periodontitis leads to entry of bacteria in the blood stream. The bacteria activate the host inflammatory response by multiple mechanisms. The host immune response favors atheroma formation, maturation and exacerbation. Epidemiology: In longitudinal studies assessing incident cardiovascular events, statistically significant excess risk for ACVD was reported in individuals with periodontitis. This was independent of established …
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MS Tonetti, TE Van Dyke… - Journal of periodontology, 2013