查看文章

BackgroundWe investigated associations between Atopobium vaginae and bacterial vaginosis (BV) and the role that A. vaginae plays in recurrent BV after oral metronidazole therapy

MethodsWomen with abnormal vaginal discharge or odor were enrolled in a cross-sectional study (n=358); the proportion of those infected with Gardnerella vaginalis and A. vaginae was determined by polymerase chain reaction. Women with BV (Nugent score [NS] 7–10 or 4–6 with ⩾3 Amsel criteria; n=139) were treated with oral metronidazole (400 mg twice a day for 7 days) and examined at 1, 3, 6, and 12 months or until they reached an NS of 7–10 and recurrence of A. vaginae and G. vaginalis infection was established

Results A. vaginae and G. vaginalis were highly sensitive for BV—96% (95% confidence interval [CI], 91%–98%) and 99% (95% CI, 97%–100%), respectively. However, A …