作者
Carla F Murillo Perez, Maren H Harms, Keith D Lindor, Henk R Van Buuren, Gideon M Hirschfield, Christophe Corpechot, Adriaan J Van Der Meer, Jordan J Feld, Aliya Gulamhusein, Willem J Lammers, Cyriel Y Ponsioen, Marco Carbone, Andrew L Mason, Marlyn J Mayo, Pietro Invernizzi, Pier Maria Battezzati, Annarosa Floreani, Ana Lleo, Frederik Nevens, Kris V Kowdley, Tony Bruns, George N Dalekos, Nikolaos K Gatselis, Douglas Thorburn, Palak J Trivedi, Xavier Verhelst, Albert Parés, Harry LA Janssen, Bettina E Hansen, GLOBAL PBC Study Group
发表日期
2020/7/1
期刊
Official journal of the American College of Gastroenterology| ACG
卷号
115
期号
7
页码范围
1066-1074
出版商
LWW
简介
METHODS:
The patient cohort from the GLOBAL PBC Study Group was used, comprising of long-term follow-up data from European and North American centers. Ursodeoxycholic acid-treated and untreated patients with bilirubin levels≤ 1× upper limit of normal (ULN) at baseline or 1 year were included. The association of normal ALP with transplant-free survival was assessed in a subgroup with ALP≤ 1.67× ULN at 1 year. Optimal thresholds of bilirubin and ALP to predict liver transplantation (LT) or death were evaluated.
RESULTS:
There were 2,281 patients included in the time zero cohort and 2,555 patients in the 1-year cohort. The bilirubin threshold with the highest ability to predict LT or death at 1 year was 0.6× ULN (hazard ratio 2.12, 95% CI 1.69–2.66, P< 0.001). The 10-year survival rates of patients with bilirubin≤ 0.6× ULN and> 0.6× ULN were 91.3% and 79.2%, respectively (P< 0.001). The risk for LT or …
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