作者
Aldo J Montano-Loza, Bettina E Hansen, Christophe Corpechot, Davide Roccarina, Douglas Thorburn, Palak Trivedi, Gideon Hirschfield, Patrick McDowell, Raoul Poupon, Jerome Dumortier, Alexie Bosch, Emiliano Giostria, Filomena Conti, Albert Parés, Anna Reig, Annarosa Floreani, Francesco Paolo Russo, Jorn C Goet, Maren H Harms, Henk van Buuren, Natalie Van den Ende, Frederik Nevens, Xavier Verhelst, Maria Francesca Donato, Federica Malinverno, Maryam Ebadi, Andrew L Mason, Global PBC Study Group
发表日期
2019/1/1
期刊
Gastroenterology
卷号
156
期号
1
页码范围
96-107. e1
出版商
WB Saunders
简介
Background & Aims
Primary biliary cholangitis (PBC) frequently recurs after liver transplantation. We evaluated risk factors associated with recurrence of PBC and its effects on patient and graft survival in a multicenter, international cohort (the Global PBC Study Group).
Methods
We collected demographic and clinical data from 785 patients (89% female) with PBC who underwent liver transplantation (mean age, 54 ± 9 years) from February 1983 through June 2016, among 13 centers in North America and Europe. Results from biochemical tests performed within 12 months of liver transplantation were analyzed to determine whether markers of cholestasis could identify patients with recurrence of PBC (based on histologic analysis). Patients were followed for a median 6.9 years (interquartile range, 6.1–7.9 years).
Results
PBC recurred in 22% of patients after 5 years and 36% after 10 years. Age at diagnosis <50 years …
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