作者
Palak J Trivedi, Tony Bruns, Angela Cheung, Ka-Kit Li, Clemens Kittler, Teru Kumagi, Husnain Shah, Christopher Corbett, Nadya Al-Harthy, Unsal Acarsu, Catalina Coltescu, Dhiraj Tripathi, Andreas Stallmach, James Neuberger, Harry LA Janssen, Gideon M Hirschfield
发表日期
2014/6/1
期刊
Journal of hepatology
卷号
60
期号
6
页码范围
1249-1258
出版商
Elsevier
简介
Background & Aims
Outcomes in primary biliary cirrhosis (PBC) can be predicted by biochemical response to ursodeoxycholic acid (UDCA). Such stratification inadequately captures cirrhosis/portal hypertension, recognised factors associated with adverse events.
Methods
We evaluated a cohort of PBC patients (n = 386) attending the Liver Unit in Birmingham (derivation cohort), seeking to identify risk-variables associated with transplant-free survival independent of UDCA-response. A validation cohort was provided through well-characterised patients attending the Toronto Center for Liver Diseases (n = 479) and Jena University Hospital (n = 150).
Results
On multivariate analysis, factors at diagnosis associated with liver transplant (LT)/death were patient age (HR:1.06; p <0.001), elevated bilirubin (HR:1.27; p <0.001), early-onset cirrhosis (HR:2.40; p <0.001) and baseline AST/platelet ratio index (APRI) (HR:1.95; p …
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PJ Trivedi, T Bruns, A Cheung, KK Li, C Kittler… - Journal of hepatology, 2014