查看文章

Autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) all nestle within the family of autoimmune liver diseases, whereby the result of immune‐mediated liver injury gives rise to varied clinical presentations. Some patients demonstrate a phenotype whereby there is evidence of either PBC or PSC together with overlapping features of AIH. Due to an absence of well‐validated diagnostic criteria and a lack of large therapeutic trials, treatment of overlap conditions is empiric and extrapolated from data derived from the primary autoimmune liver diseases.

To review overlaps in the context of autoimmune liver diseases.

General and specific review of published articles using PubMed, Medline and Ovid search engines, alongside pre‐existing clinical management protocols, guidelines, and the authors' own knowledge of the published literature …