作者
VM Patil, K Prabhash, V Noronha, A Joshi, V Muddu, S Dhumal, S Arya, S Juvekar, P Chaturvedi, D Chaukar, P Pai, S Kane, A Patil, JP Agarwal, S Ghosh-Lashkar, A Dcruz
发表日期
2014/10/1
期刊
Oral oncology
卷号
50
期号
10
页码范围
1000-1004
出版商
Pergamon
简介
Background
The median survival of technically unresectable oral-cavity cancers (T4a and T4b) with non surgical therapy is 2–12 months. We hypothesized that neoadjuvant chemotherapy (NACT) could reduce the tumour size and result in successful resection and ultimately improved outcomes. We present a retrospective analysis of consecutive patients who received NACT at our centre between January 2008 and August 2012.
Patients and methods
All patients with technically unresectable oral cancers were assessed in a multidisciplinary clinic and received 2 cycles of NACT. After 2 cycles, patients were reassessed and planned for either surgery with subsequent CTRT or nonsurgical therapy including CT-RT, RT or palliation. SPSS version 16 was used for analysis of locoregional control and overall survival (OS). Univariate and multivariate analysis was done for factors affecting the OS.
Results
721 patients with …
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VM Patil, K Prabhash, V Noronha, A Joshi, V Muddu… - Oral oncology, 2014