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Heavy metal contamination of water body has become a serious threat to aquatic life forms specially to fish. Hexavalent chromium (Cr [VI]) is one of the most potent heavy metal toxicant. It is present in aquatic environment at concentrations beyond permissible limit. Considering the fact that toxic effects are function of the exposure concentration, studies involving toxicological risk assessment should be done at environmentally relevant concentration. Therefore we studied the toxic effects of Cr [VI] to zebrafish at an environmentally relevant concentration (2 mg L⁻¹). We monitored the genotoxic potential of Cr [VI] in erythrocytes through a simple reliable microscopic assay and found an increase in frequency of micronucleated erythrocytes along with erythrocytes with blebbed, lobed and notched nuclei. In addition, Cr [VI] induced neurotoxicity, being a least reported event was also investigated. Histological alterations …