作者
Martin Farlow, Stephen I Gracon, Linda A Hershey, Karen W Lewis, Carl H Sadowsky, Jann Dolan-Ureno, Stephen W Asher, Craig Beaver, Diane Hamilton, Scott M Bergman, Linda F Roger, Sandra E Black, Sandra Carr, Tamara Winchester, Elizabeth Layne, Christopher Clark, James Dexter, Eugene A DuBoff, Hugh Hendrie, Judy Caress, Rhonna Shatz, George R Hanna, H Robert Brashear, Paula Damgaard, Kerry Donnelly, Karen Burch, Richard W Homan, A John McSweeney, Mary Ann Barczak, Jeffrey A Mattes, Allison M Hermann, Erich Mohr, Tilak Mendis, Jeremy Roberts, Linda Begin, Margaret Sampson, Brian R Ott, Margaret C Lannon, J Joseph Prendergast, Sherna Madan, Roxann Hanning, Walter Martinez, Reed Stone, Paul Winner, Jose Zuniga, Laszlo J Mate, BJ Ehlert, Caria Lessard, Benjamin Seltzer, John R Taylor, VP Calabrese, SW Harkins, SJ Weis, Walter Slade, Barbara R Sommer, Melvin Wichter, Michael Schwartz, Joey Eastman, Stephen G Thein, Geri Williams, Judith A Dewar, Norman L Foster, Laurie A Bluemlein, Douglas J Gelb, Stanley Berent, Bruno Giordani, Beth A Baron, Sharie Myers
发表日期
1992/11/11
期刊
Jama
卷号
268
期号
18
页码范围
2523-2529
出版商
American Medical Association
简介
Objective
—To compare efficacy and safety of tacrine hydrochloride with placebo in patients with probable Alzheimer's disease.
Design
—A 12-week, double-blind, placebo-controlled, parallel-group study.
Setting
—Outpatients at 23 centers.
Patients
—Men and women with probable Alzheimer's disease, at least 50 years old, mildly to moderately impaired, without other significant medical conditions.
Interventions
—In the initial 6 weeks, patients received placebo, 20 mg/d of tacrine, or 40 mg/d of tacrine. In the second 6 weeks, half received the same treatment and half increased tacrine dose: those receiving placebo increased to 20 mg/d, those receiving 20 mg/d increased to 40 mg/d, and those receiving 40 mg/d increased to 80 mg/d.
Primary Outcome Measures
—Alzheimer's Disease Assessment Scale (ADAS) cognitive component and clinician-rated Clinical Global Impression of Change (CGIC).
Results
—Four …
引用总数
学术搜索中的文章
M Farlow, SI Gracon, LA Hershey, KW Lewis… - Jama, 1992