作者
Pasi K Korhonen, Liina Kinkar, Neil D Young, Huimin Cai, Marshall W Lightowlers, Charles Gauci, Abdul Jabbar, Bill CH Chang, Tao Wang, Andreas Hofmann, Anson V Koehler, Junhua Li, Jiandong Li, Daxi Wang, Jiefang Yin, Huanming Yang, David J Jenkins, Urmas Saarma, Teivi Laurimäe, Mohammad Rostami-Nejad, Malik Irshadullah, Hossein Mirhendi, Mitra Sharbatkhori, Francisco Ponce-Gordo, Sami Simsek, Adriano Casulli, Houria Zait, Hripsime Atoyan, Mario Luiz de la Rue, Thomas Romig, Marion Wassermann, Sargis A Aghayan, Hasmik Gevorgyan, Bicheng Yang, Robin B Gasser
发表日期
2022/3/3
期刊
Communications biology
卷号
5
期号
1
页码范围
199
出版商
Nature Publishing Group UK
简介
Cystic echinococcosis is a socioeconomically important parasitic disease caused by the larval stage of the canid tapeworm Echinococcus granulosus, afflicting millions of humans and animals worldwide. The development of a vaccine (called EG95) has been the most notable translational advance in the fight against this disease in animals. However, almost nothing is known about the genomic organisation/location of the family of genes encoding EG95 and related molecules, the extent of their conservation or their functions. The lack of a complete reference genome for E. granulosus genotype G1 has been a major obstacle to addressing these areas. Here, we assembled a chromosomal-scale genome for this genotype by scaffolding to a high quality genome for the congener E. multilocularis, localised Eg95 gene family members in this genome, and evaluated the conservation of the EG95 vaccine molecule. These …
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