作者
Hanna Kuzior, Bernd L Fiebich, Nizar M Yousif, Soraya W Saliba, Christiane Ziegler, Kathrin Nickel, Simon J Maier, Patrick Suess, Kimon Runge, Miriam Matysik, Rick Dersch, Benjamin Berger, Tilman Robinson, Nils Venhoff, Franziska Kessler, Thomas Blank, Katharina Domschke, Ludger Tebartz van Elst, Dominique Endres
发表日期
2020/10/1
期刊
Comprehensive Psychiatry
卷号
102
页码范围
152196
出版商
WB Saunders
简介
Introduction
Unipolar depression is a common and debilitating disorder. Immunological explanatory approaches have become increasingly important in recent years and can be studied particularly well in the cerebrospinal fluid (CSF). Previous studies discerned alterations in interleukin (IL)-6 and IL-8 levels; however, findings regarding IL-8 were partly contradictory. The aim of the present study was to investigate the concentrations of different cytokines and chemokines, focusing on IL-8, in the CSF of patients with unipolar depression.
Materials and methods
Participants included 40 patients with unipolar depression and 39 mentally healthy controls with idiopathic intracranial hypertension. CSF cytokine levels were measured using a magnetic bead multiplexing immunoassay.
Results
IL-8 levels in the CSF of the patient group with depression were significantly higher than those in the control group (Mean ± SD: 38.44 ± …
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H Kuzior, BL Fiebich, NM Yousif, SW Saliba, C Ziegler… - Comprehensive Psychiatry, 2020