作者
Thomas A Burgess, Michael P Robich, Louis M Chu, Cesario Bianchi, Frank W Sellke
发表日期
2011/5/1
期刊
Archives of surgery
卷号
146
期号
5
页码范围
556-564
出版商
American Medical Association
简介
Hypothesis
We hypothesized that supplemental resveratrol would affect glucose metabolism in the skeletal muscle and liver to improve blood glucose control.
Design
Case-control study.
Setting
Hospital laboratory.
Subjects
Yorkshire miniswine.
Intervention
The swine developed metabolic syndrome by consuming a high-calorie, high–fat/cholesterol diet for 11 weeks. Pigs were fed either a normal diet (control) (n = 7), a hypercholesterolemic diet (HCC) (n = 7), or a hypercholesterolemic diet with supplemental resveratrol (100 mg/kg/d) (HCRV) (n = 7). Animals underwent dextrose challenge prior to euthanasia and tissue collection.
Main Outcome Measures
Measurements of glucose and insulin levels, skeletal muscle and liver protein expression, and liver function test results.
Results
The HCC group had significantly increased blood glucose levels at 30 minutes as compared with the control and HCRV groups. The HCC …
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TA Burgess, MP Robich, LM Chu, C Bianchi, FW Sellke - Archives of surgery, 2011