作者
Michael P Robich, Louis M Chu, Mirnal Chaudray, Reza Nezafat, Yuchi Han, Richard T Clements, Roger J Laham, Warren J Manning, Michael A Coady, Frank W Sellke
发表日期
2010/8/1
期刊
Surgery
卷号
148
期号
2
页码范围
453-462
出版商
Mosby
简介
BACKGROUND
Resveratrol has been reported to induce angiogenesis in ischemic tissue. We hypothesized that high-dose resveratrol would improve native angiogenesis in a swine model of metabolic syndrome and chronic myocardial ischemia.
METHODS
Yorkshire swine were fed a normal diet (Control, n = 7), hypercholesterolemic diet (HCD, n = 7), or hypercholesterolemic diet with supplemental resveratrol (100 mg/kg/day orally, HCD-R; n = 7) beginning 1 month prior to surgery. Chronic ischemia was created by placing an ameroid constrictor on the left circumflex coronary artery. After 7 weeks, swine underwent functional MRI, coronary angiography, and serum and heart tissue harvest for analysis.
RESULTS
HCD-R animals had lower body mass index (P < .001), total cholesterol (P < .001), low-density lipoprotein (LDL; P < .001), blood glucose levels (P < .001), and systolic blood pressure (P = .03) than HCD …
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MP Robich, LM Chu, M Chaudray, R Nezafat, Y Han… - Surgery, 2010