作者
Julian Gendreau, Adrian Jimenez, Shannon Lozinsky, Georgios Zenonos, Paul Gardner, Shaan Raza, Nicolas Dea, Ziya Gokaslan, Garret Choby, Jamie Van Gompel, Kristin Redmond, Gary Gallia, Chetan Bettegowda, Nicholas Rowan, Cathleen C Kuo, Debraj Mukherjee
发表日期
2023/4/1
期刊
World neurosurgery
卷号
172
页码范围
e68-e76
出版商
Elsevier
简介
Objective
Skull base chordoma is a rare and locally destructive malignancy which presents unique therapeutic challenges. While achieving gross total resection (GTR) confers the greatest survival advantage, the role of adjuvant radiotherapy (RT) for patients who receive GTR remains unclear in the absence of prospective trials. Here, we aim to assess the effect of RT on survival outcomes in skull base chordoma patients who receive GTR by utilizing the Surveillance, Epidemiology, and End Results (SEER) database.
Methods
Patients with diagnostic, primary site, and resection codes specific for chordoma, skull base, and GTR, respectively, were queried in the SEER database (2000–2018). Kaplan-Meier curves (log-rank test) were constructed and Cox proportional hazards models were used to assess survival outcomes.
Results
A total of 115 skull base chordomas undergoing GTR were identified, of which 37 (32 …
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J Gendreau, A Jimenez, S Lozinsky, G Zenonos… - World neurosurgery, 2023