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The objective of this study was to evaluate the oil extraction process from Camelina sativa (L.) Crantz seeds by screw pressing followed by extraction with supercritical CO₂. In pressing experiments, the response surface methodology (RSM) was conducted in order to study the effects of temperature, frequency and nozzle size on oil recovery and quality parameters. The optimal condition to obtain the highest oil recovery and the best oil quality within the experimental range of the variables studied was at temperature of 52 °C, frequency of 20 Hz and using nozzle of ID 9 mm. The experimental values agreed with those predicted, thus indicating suitability of the used models and the success of RSM in optimizing the pressing conditions of investigated system. The cake resulting from pressing at optimal conditions was extracted with CO₂ in a new designed and built a homemade supercritical fluid extraction system. The …