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Due to the interesting anti-proliferative properties of copper–thiosemicarbazone complexes, the production of a ⁶¹Cu-labeled thiosemicarbazone, i.e. 2-acetylpyridine thiosemicarbazone (APTS) was investigated. Copper-61 (T_1/2=3.33h) was produced via the ⁶⁴Zn(p,α)⁶¹Cu nuclear reaction using a natural zinc target irradiated with 22MeV protons for 500μAh. The ⁶¹Cu was separated from the irradiated target material by a two-step method and converted to acetate; this yielded a final activity of 222GBq (6.0Ci), with a radiochemical yield of >95%. The ⁶¹Cu–acetate was mixed with 2-acetylpyridine thiosemicarbazone for 30min at room temperature to yield [⁶¹Cu]APTS with a radiochemical yield of more than 80%. Colorimetric methods showed that residual chemical impurities in the product were below the accepted limits. Radio thin layer chromatography (RTLC) showed a radiochemical purity of more than 99 …