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Cardiovascular disease is the main cause of death around the world [1]. Increasing the concentration of LDL cholesterol is a major risk factor for cardiovascular disease [2]. According to statistics published, more than one hundred million Americans are infected with hypercholesterolemia and approximately 50 million of these people are in need of treatment [3, 4]. High levels of fat can harden the arteries, or accelerate the atherosclerosis process and it is considered as one of the five leading causes of death in the world [5]. The manner of the metabolism, the amount and type of plasma fats, especially lipoproteins in triggering and exacerbating the cardiovascular disease are effective [6]. Considerable evidence exist that reducing cholesterol-LDL, through diet or through the use of lipid-lowering agents, primarily statins, can reduce the incidence of cardiovascular disease [7-10]. Chemical synthetic lipid-lowering medications have the side effects. Recently the use of remedies and natural herbs has been prevalent because people and are doctors have always been looking for effective, fast and low cost treatments. Among the medicinal plants in traditional medicine can be pointed to the celery with multiple health benefits. Celery (Apium graveolens) is a two-year plant with aromatic, branched stems and belongs to the family Apiaceae [11]. This plant is native to the Mediterranean region that is cultivated in other parts of the world [12]. Leaves and stalks of celery contain phenols, furanocoumarin, psoralen, bergapten, fully and xanthotoxin that their amount is changing from 12 to 50 mg/kg [13].