作者
Jeong-a Kim, Monica Montagnani, Kwang Kon Koh, Michael J Quon
发表日期
2006/4/18
来源
Circulation
卷号
113
期号
15
页码范围
1888-1904
出版商
Lippincott Williams & Wilkins
简介
Endothelial dysfunction contributes to cardiovascular diseases, including hypertension, atherosclerosis, and coronary artery disease, which are also characterized by insulin resistance. Insulin resistance is a hallmark of metabolic disorders, including type 2 diabetes mellitus and obesity, which are also characterized by endothelial dysfunction. Metabolic actions of insulin to promote glucose disposal are augmented by vascular actions of insulin in endothelium to stimulate production of the vasodilator nitric oxide (NO). Indeed, NO-dependent increases in blood flow to skeletal muscle account for 25% to 40% of the increase in glucose uptake in response to insulin stimulation. Phosphatidylinositol 3-kinase–dependent insulin-signaling pathways in endothelium related to production of NO share striking similarities with metabolic pathways in skeletal muscle that promote glucose uptake. Other distinct nonmetabolic …
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J Kim, M Montagnani, KK Koh, MJ Quon - Circulation, 2006