作者
M Casula, M Gazzotti, F Bonaiti, E OImastroni, M Arca, M Averna, A Zambon, AL Catapano, PROSISA Study Group, Marcello Arca, Anna Montali, Maurizio Averna, Antonina Giammanco, Gianni Biolo, Pierandrea Vinci, Claudio Borghi, Sergio D’Addato, Antonio Carlo Bossi, Giancarla Meregalli, Adriana Branchi, Giovanna Squiccimarro, Franco Cavalot, Linda Ramadori, Francesco Cipollone, Marco Bucci, Maria Del Ben, Francesco Angelico, Anna Maria Fiorenza, Emanuela Colombo, Liliana Grigore, Veronica Zampoleri, Graziana Lupattelli, Vito Gandolfo, Giuseppe Mandraffino, Francesca Savarino, Giuliana Mombelli, Chiara Pavanello, Livia Pisciotta, Andrea Pasta, Francesco Purrello, Roberto Scicali, Paolo Rubba, Giuliana Fortunato, Carlo Sabbà, Patrizia Suppressa, Riccardo Sarzani, Chiara Di Pentima, Giovanni Battista Vigna, Angela Colangiulo, Josè Pablo Werba, Lorenzo Maria Vigo, Sabina Zambon, Lorenzo Previato, Maria Grazia Zenti, Chiara Maneschi
发表日期
2021/7
期刊
Journal of Internal Medicine
卷号
290
期号
1
页码范围
116-128
简介
Aim
Statin‐associated muscle symptoms (SAMS) are a major determinant of poor treatment adherence and/or discontinuation, but a definitive diagnosis of SAMS is challenging. The PROSISA study was an observational retrospective study aimed to assess the prevalence of reported SAMS in a cohort of dyslipidaemic patients.
Methods
Demographic/anamnestic data, biochemical values and occurrence of SAMS were collected by 23 Italian Lipid Clinics. Adjusted logistic regression was performed to estimate odds ratio (OR) and 95% confidence intervals for association between probability of reporting SAMS and several factors.
Results
Analyses were carried out on 16 717 statin‐treated patients (mean ± SD, age 60.5 ± 12.0 years; 52.1% men). During statin therapy, 9.6% (N = 1599) of patients reported SAMS. Women and physically active subjects were more likely to report SAMS (OR 1.23 [1.10–1.37] and OR 1 …
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M Casula, M Gazzotti, F Bonaiti, E OImastroni, M Arca… - Journal of Internal Medicine, 2021