作者
Melvin Parasram, J Levi Chazen, Harini Sarva
发表日期
2020/11/1
期刊
Journal of Osteopathic Medicine
卷号
120
期号
11
页码范围
808-808
出版商
American Osteopathic Association
简介
A61-year-old woman presented with recurrent falls, worsening gait, and dysarthria. She was given a diagnosis of primary familial brain calcification (PFBC), or Fahr disease, 3 years prior after developing gait difficulty, declining motor function, and dysarthria. Prior noncontrast computed tomography of the head revealed bilateral and symmetric basal ganglia calcifications. An extensive workup revealed no secondary causes of intracranial calcifications. Carbidopa-levodopa was ineffective. Examination demonstrated poor recall, dysarthria, right arm spasticity, left arm bradykinesia, and a wide-based, shuffling gait. Laboratory testing was unremarkable. The extent of calcification and clinical correlates excluded physiological calcifications. 1 The patient’s presentation and computed tomography of head were consistent with PFBC (image). 2, 3 PFBC is a primary neurodegenerative disorder, characterized by symmetric …
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M Parasram, J Levi Chazen, H Sarva - Journal of Osteopathic Medicine, 2020