作者
Richard M Cubbon, Christopher P Gale, Lorraine C Kearney, Clyde B Schechter, W Paul Brooksby, Jim Nolan, Keith AA Fox, Adil Rajwani, Wazir Baig, David Groves, Pauline Barlow, Anthony C Fisher, Phillip D Batin, Matthew B Kahn, Azfar G Zaman, Ajay M Shah, Jon A Byrne, Steven J Lindsay, Robert J Sapsford, Stephen B Wheatcroft, Klaus K Witte, Mark T Kearney
发表日期
2011/7
期刊
Circulation: Heart Failure
卷号
4
期号
4
页码范围
396-403
出版商
Lippincott Williams & Wilkins
简介
Background
Therapies for patients with chronic heart failure caused by left ventricular systolic dysfunction have advanced substantially over recent decades. The cumulative effect of these therapies on mortality, mode of death, symptoms, and clinical characteristics has yet to be defined.
Methods and Results
This study was a comparison of 2 prospective cohort studies of outpatients with chronic heart failure caused by left ventricular systolic dysfunction performed between 1993 and 1995 (historic cohort: n=281) and 2006 and 2009 (contemporary cohort: n=357). In the historic cohort, 83% were prescribed angiotensin-converting enzyme inhibitors and 8.5% were prescribed β-adrenoceptor antagonists, compared with 89% and 80%, respectively, in the contemporary cohort. Mortality rates over the first year of follow-up declined from 12.5% to 7.8% between eras (P=0.04), and sudden death contributed less to …
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RM Cubbon, CP Gale, LC Kearney, CB Schechter… - Circulation: Heart Failure, 2011
