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Evaluate the effects of a low-intensity resistance training program associated with partial blood flow restriction on selected clinical outcomes in patients with knee osteoarthritis (OA). Forty-eight women with knee OA were randomized into one of the three groups: low-intensity resistance training (30% one repetition maximum 1-RM) associated (BFRT) or not (LI-RT) with partial blood flow restriction, and high-intensity resistance training (HI-RT: 80% 1-RM). Patients underwent a 12-week supervised training program and were assessed for lower-limb 1-RM, quadriceps cross-sectional area (CSA), functionality (timedstands test-TST and timed-up-and-go test-TUG), and disease-specific inventory (Western Ontario and McMaster Universities Osteoarthritis Index-WOMAC) before (PRE) and after the protocol (POST). Similar within-group increases were observed in leg-press (26% and 33%, all p< 0.0001), knee-extension 1-RM (23% and 22%; all p< 0.0001) and CSA (7% and 8%; all p< 0.0001) in BFRT and HI-RT, respectively, and these were significantly greater (all p< 0.05) than those of LI-RT. BFRT and HI-RT showed comparable improvements in TST (7% and 14%, respectively), with the latter showing greater increases than LI-RT. TUG scores were not significantly changed within or between groups. WOMAC physical function was improved in BFRT and HI-RT (-49% and-42%, respectively; all p< 0.05), and WOMAC pain was improved in BFRT and LI-RT (-45% and-39%, respectively; all p< 0.05). Four patients (out of 16) were excluded due to exercise-induced knee pain in HI-RT. BFRT and HI-RT were similarly …