作者
Peter T Nelson, Edward B Lee, Matthew D Cykowski, Irina Alafuzoff, Konstantinos Arfanakis, Johannes Attems, Carol Brayne, Maria M Corrada, Brittany N Dugger, Margaret E Flanagan, Bernardino Ghetti, Lea T Grinberg, Murray Grossman, Michel J Grothe, Glenda M Halliday, Masato Hasegawa, Suvi RK Hokkanen, Sally Hunter, Kurt Jellinger, Claudia H Kawas, C Dirk Keene, Naomi Kouri, Gabor G Kovacs, James B Leverenz, Caitlin S Latimer, Ian R Mackenzie, Qinwen Mao, Kirsty E McAleese, Richard Merrick, Thomas J Montine, Melissa E Murray, Liisa Myllykangas, Sukriti Nag, Janna H Neltner, Kathy L Newell, Robert A Rissman, Yuko Saito, S Ahmad Sajjadi, Katherine E Schwetye, Andrew F Teich, Dietmar R Thal, Sandra O Tomé, Juan C Troncoso, Shih-Hsiu J Wang, Charles L White III, Thomas Wisniewski, Hyun-Sik Yang, Julie A Schneider, Dennis W Dickson, Manuela Neumann
发表日期
2023/2
期刊
Acta neuropathologica
卷号
145
期号
2
页码范围
159-173
出版商
Springer Berlin Heidelberg
简介
An international consensus report in 2019 recommended a classification system for limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC). The suggested neuropathologic staging system and nomenclature have proven useful for autopsy practice and dementia research. However, some issues remain unresolved, such as cases with unusual features that do not fit with current diagnostic categories. The goal of this report is to update the neuropathologic criteria for the diagnosis and staging of LATE-NC, based primarily on published data. We provide practical suggestions about how to integrate available genetic information and comorbid pathologies [e.g., Alzheimer’s disease neuropathologic changes (ADNC) and Lewy body disease]. We also describe recent research findings that have enabled more precise guidance on how to differentiate LATE-NC from other subtypes of …
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PT Nelson, EB Lee, MD Cykowski, I Alafuzoff… - Acta neuropathologica, 2023