作者
Scott M Lippman, Eric A Klein, Phyllis J Goodman, M Scott Lucia, Ian M Thompson, Leslie G Ford, Howard L Parnes, Lori M Minasian, J Michael Gaziano, Jo Ann Hartline, J Kellogg Parsons, James D Bearden, E David Crawford, Gary E Goodman, Jaime Claudio, Eric Winquist, Elise D Cook, Daniel D Karp, Philip Walther, Michael M Lieber, Alan R Kristal, Amy K Darke, Kathryn B Arnold, Patricia A Ganz, Regina M Santella, Demetrius Albanes, Philip R Taylor, Jeffrey L Probstfield, TJ Jagpal, John J Crowley, Frank L Meyskens, Laurence H Baker, Charles A Coltman
发表日期
2009/1/7
期刊
Jama
卷号
301
期号
1
页码范围
39-51
出版商
American Medical Association
简介
Context
Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer.
Objective
To determine whether selenium, vitamin E, or both could prevent prostate cancer and other diseases with little or no toxicity in relatively healthy men.
Design, Setting, and Participants
A randomized, placebo-controlled trial (Selenium and Vitamin E Cancer Prevention Trial [SELECT]) of 35 533 men from 427 participating sites in the United States, Canada, and Puerto Rico randomly assigned to 4 groups (selenium, vitamin E, selenium + vitamin E, and placebo) in a double-blind fashion between August 22, 2001, and June 24, 2004. Baseline eligibility included age 50 years or older (African American men) or 55 years or older (all other men), a serum prostate-specific antigen level of 4 ng/mL or less, and a digital rectal …
引用总数
学术搜索中的文章
SM Lippman, EA Klein, PJ Goodman, MS Lucia… - Jama, 2009