作者
Alessandra Tiziana Peana, Paolo Stefano D'Aquila, Francesca Panin, Gino Serra, Proto Pippia, Mario Domenico Luigi Moretti
发表日期
2002/1/1
期刊
Phytomedicine
卷号
9
期号
8
页码范围
721-726
出版商
Urban & Fischer
简介
Linalool and linalyl acetate are the principal components of many essential oils known to possess several biological activities, attributable to these monoterpene compounds. In this work, we evaluated individually the anti-inflammatory properties of (–) linalool, that is, the natural occurring enantiomer, and its racemate form, present in various amounts in distilled or extracted essential oils. Because in the linalool-containing essential oils, linalyl acetate, is frequently present, we also examined the anti-inflammatory action of this monoterpene ester. Carrageenin-induced edema in rats was used as a model of inflammation. The experimental data indicate that both the pure enantiomer and its racemate induced, after systemic administration, a reduction of edema. Moreover, the pure enantiomer, at a dose of 25 mg/kg, elicited a delayed and more prolonged effect, while the racemate form induced a significant reduction of …
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