作者
S D Paolo, Alessandra T Peana, Francesca Panin, Chiara Grixoni, Maria Cossu, Gino Serra
发表日期
2003/1/1
期刊
European journal of pharmacology
卷号
458
期号
1-2
页码范围
129-134
出版商
Elsevier
简介
Chronic antidepressant treatments enhance dopaminergic neurotransmission in the mesolimbic dopamine system. We suggested that this potentiation might underlie both the antidepressant therapeutic effect and the antidepressant-induced switch from depression to mania, which in turn, might be involved in the development of rapid cycling in bipolar patients. In this study, we investigated the changes occurring in the sensitivity of the mesolimbic dopamine system up to 40 days after antidepressant withdrawal. Male Sprague–Dawley rats were treated for 3 weeks with imipramine (20 mg/kg) and tested for motor activity 24 h, 12, 33 and 40 days after treatment withdrawal. Ambulatory activity and rearing counts were recorded after challenge with the dopamine D2-like receptor agonist quinpirole (0.15 mg/kg). Imipramine increased the motor response to quinpirole, 24 h after treatment discontinuation. No relevant …
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SD Paolo, AT Peana, F Panin, C Grixoni, M Cossu… - European journal of pharmacology, 2003