作者
Hui Shen, Juliann Shih, Daniel P Hollern, Linghua Wang, Reanne Bowlby, Satish K Tickoo, Vésteinn Thorsson, Andrew J Mungall, Yulia Newton, Apurva M Hegde, Joshua Armenia, Francisco Sánchez-Vega, John Pluta, Louise C Pyle, Rohit Mehra, Victor E Reuter, Guilherme Godoy, Jeffrey Jones, Carl S Shelley, Darren R Feldman, Daniel O Vidal, Davor Lessel, Tomislav Kulis, Flavio M Cárcano, Kristen M Leraas, Tara M Lichtenberg, Denise Brooks, Andrew D Cherniack, Juok Cho, David I Heiman, Katayoon Kasaian, Minwei Liu, Michael S Noble, Liu Xi, Hailei Zhang, Wanding Zhou, Jean C ZenKlusen, Carolyn M Hutter, Ina Felau, Jiashan Zhang, Nikolaus Schultz, Gad Getz, Matthew Meyerson, Joshua M Stuart, David Wheeler, Daniel Hughes, Kyle Covington, Joy C Jayaseelan, Viktoriya Korchina, Lora Lewis, Jianhong Hu, HarshaVardhan Doddapaneni, Donna Muzny, Richard Gibbs, Katherine A Hoadley, Daniel Hollern, Benjamin G Vincent, Shengjie Chai, Christof C Smith, J Todd Auman, Yan Shi, Shaowu Meng, Tara Skelly, Donghui Tan, Umadevi Veluvolu, Piotr A Mieczkowski, Corbin D Jones, Matthew D Wilkerson, Saianand Balu, Tom Bodenheimer, Alan P Hoyle, Stuart R Jefferys, Lisle E Mose, Janae V Simons, Matthew G Soloway, Jeffrey Roach, Joel S Parker, D Neil Hayes, Charles M Perou, Gordon Saksena, Carrie Cibulskis, Steven E Schumacher, Rameen Beroukhim, Stacey B Gabriel, Adrian Ally, Miruna Balasundaram, Rebecca Carlsen, Dorothy Cheung, Eric Chuah, Noreen Dhalla, Robert A Holt, Steven JM Jones, Yussanne Ma, Michael Mayo, Richard A Moore, A Gordon Robertson, Jacqueline E Schein, Payal Sipahimalani, Angela Tam, Nina Thiessen, Tina Wong, Marco A Marra, Peter W Laird, Daniel J Weisenberger, David J Van Den Berg, Phillip H Lai, Mario Berrios, Andrea Holbrook, Moiz S Bootwalla, Dennis T Maglinte, Debyani Chakravarty, Jianjiong Gao, Zachary Heins, Ritika Kundra, Angelica Ochoa, Chris Sander, Marc Ladanyi, Vesteinn Thorsson, Amie J Radenbaugh, Nils Gehlenborg, Doug Voet, Pei Lin, Scott Frazer, Jaegil Kim, Michael S Lawrence, Sam Meier, Timothy Defreitas, Lynda Chin, Rehan Akbani, John N Weinstein, Wenbin Liu, Gordon B Mills, Yiling Lu, Katherine L Nathanson, Leendert Looijenga, Alan H Bryce, André L Carvalho, Victoria K Cortessis, Darren Feldman, Michael Ittmann, Seth Lerner, Jay Bowen, Julie M Gastier-Foster, Mark Gerken, Carmen Helsel, Nilsa C Ramirez, Lisa Wise, Erik Zmuda, Sandra Cottingham, David Chesla
发表日期
2018/6/12
期刊
Cell reports
卷号
23
期号
11
页码范围
3392-3406
出版商
Elsevier
简介
We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutation of only three genes achieved significance—KIT, KRAS, and NRAS—exclusively in samples with seminoma components. Integrated analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryonal carcinoma, yolk sac tumor, and teratoma. Striking differences in global DNA methylation and microRNA expression between histology subtypes highlight a likely role of epigenomic processes in determining histologic fates in TGCTs. We also identified a subset of pure seminomas defined by KIT mutations, increased immune infiltration, globally demethylated DNA, and decreased KRAS copy number …
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H Shen, J Shih, DP Hollern, L Wang, R Bowlby… - Cell reports, 2018