作者
Benjamin J Raphael, Ralph H Hruban, Andrew J Aguirre, Richard A Moffitt, Jen Jen Yeh, Chip Stewart, A Gordon Robertson, Andrew D Cherniack, Manaswi Gupta, Gad Getz, Stacey B Gabriel, Matthew Meyerson, Carrie Cibulskis, Suzanne S Fei, Toshinori Hinoue, Hui Shen, Peter W Laird, Shiyun Ling, Yiling Lu, Gordon B Mills, Rehan Akbani, Phillipe Loher, Eric R Londin, Isidore Rigoutsos, Aristeidis G Telonis, Ewan A Gibb, Anna Goldenberg, Aziz M Mezlini, Katherine A Hoadley, Eric Collisson, Eric Lander, Bradley A Murray, Julian Hess, Mara Rosenberg, Louis Bergelson, Hailei Zhang, Juok Cho, Grace Tiao, Jaegil Kim, Dimitri Livitz, Ignaty Leshchiner, Brendan Reardon, Eliezer Van Allen, Atanas Kamburov, Rameen Beroukhim, Gordon Saksena, Steven E Schumacher, Michael S Noble, David I Heiman, Nils Gehlenborg, Michael S Lawrence, Volkan Adsay, Gloria Petersen, David Klimstra, Nabeel Bardeesy, Mark DM Leiserson, Reanne Bowlby, Katayoon Kasaian, Inanc Birol, Karen L Mungall, Sara Sadeghi, John N Weinstein, Paul T Spellman, Yuexin Liu, Laufey T Amundadottir, Joel Tepper, Aatur D Singhi, Rajiv Dhir, Drwiega Paul, Thomas Smyrk, Lizhi Zhang, Paula Kim, Jay Bowen, Jessica Frick, Julie M Gastier-Foster, Mark Gerken, Kevin Lau, Kristen M Leraas, Tara M Lichtenberg, Nilsa C Ramirez, Jeremy Renkel, Mark Sherman, Lisa Wise, Peggy Yena, Erik Zmuda, Juliann Shih, Adrian Ally, Miruna Balasundaram, Rebecca Carlsen, Andy Chu, Eric Chuah, Amanda Clarke, Noreen Dhalla, Robert A Holt, Steven JM Jones, Darlene Lee, Yussanne Ma, Marco A Marra, Michael Mayo, Richard A Moore, Andrew J Mungall, Jacqueline E Schein, Payal Sipahimalani, Angela Tam, Nina Thiessen, Kane Tse, Tina Wong, Denise Brooks, J Todd Auman, Saianand Balu, Tom Bodenheimer, D Neil Hayes, Alan P Hoyle, Stuart R Jefferys, Corbin D Jones, Shaowu Meng, Piotr A Mieczkowski, Lisle E Mose, Charles M Perou, Amy H Perou, Jeffrey Roach, Yan Shi, Janae V Simons, Tara Skelly, Matthew G Soloway, Donghui Tan, Umadevi Veluvolu, Joel S Parker, Matthew D Wilkerson, Anil Korkut, Yasin Senbabaoglu, Patrick Burch, Robert McWilliams, Kari Chaffee, Ann Oberg, Wei Zhang, Marie-Claude Gingras, David A Wheeler, Liu Xi, Monique Albert, John Bartlett, Harman Sekhon, Yeager Stephen, Zaren Howard, Miller Judy, Anne Breggia, Rachna T Shroff, Sudha Chudamani, Jia Liu, Laxmi Lolla
发表日期
2017/8/14
期刊
Cancer cell
卷号
32
期号
2
页码范围
185-203. e13
出版商
Elsevier
简介
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low neoplastic cellularity. Deep whole-exome sequencing revealed recurrent somatic mutations in KRAS, TP53, CDKN2A, SMAD4, RNF43, ARID1A, TGFβR2, GNAS, RREB1, and PBRM1. KRAS wild-type tumors harbored alterations in other oncogenic drivers, including GNAS, BRAF, CTNNB1, and additional RAS pathway genes. A subset of tumors harbored multiple KRAS mutations, with some showing evidence of biallelic mutations. Protein profiling identified a favorable prognosis subset with low epithelial-mesenchymal transition and high MTOR pathway scores. Associations of non-coding RNAs with tumor-specific mRNA subtypes were also identified. Our integrated multi-platform analysis reveals a complex molecular landscape of PDAC …
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