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Background: Cognitive decline may be exacerbated, in brain tumour patients, by prior radiotherapy (RT). Traditional interventions to mitigate this typically involve fixed dose or intensity pharmacological and/or cognitive rehabilitation therapies that often elicit sub-optimal or no response, due to the dynamically evolving patient state and low adherence. Personalised digital therapeutics (DTx) may be more effective for this population. Further, gamification has previously shown to induce positive health behavioural change and improve intervention adherence. To this end, we have developed the CURATE.AI COR-Tx platform, a gamified DTx, that combines a previously validated, small-data artificial intelligence-derived dose optimisation technology with digital multitasking cognitive training. This novel DTx dynamically personalises treatment by using the patient’s own longitudinal performance data to generate …