作者
Sandra Rodríguez-Rodero, Agustín F Fernández, Juan Luís Fernández-Morera, Patricia Castro-Santos, Gustavo F Bayon, Cecilia Ferrero, Rocio G Urdinguio, Rocío Gonzalez-Marquez, Carlos Suarez, Iván Fernández-Vega, Manuel Florentino Fresno Forcelledo, Pablo Martínez-Camblor, Veronika Mancikova, Esmeralda Castelblanco, Marco Perez, Pablo Isidro Marrón, Marta Mendiola, David Hardisson, Pilar Santisteban, Garcilaso Riesco-Eizaguirre, Xavier Matías-Guiu, Amancio Carnero, Mercedes Robledo, Elías Delgado-Álvarez, Edelmiro Menéndez-Torre, Mario F Fraga
发表日期
2013/7/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
98
期号
7
页码范围
2811-2821
出版商
Oxford University Press
简介
Objective
The purpose of this study was to determine the global patterns of aberrant DNA methylation in thyroid cancer.
Research Design and Methods
We have used DNA methylation arrays to determine, for the first time, the genome-wide promoter methylation status of papillary, follicular, medullary, and anaplastic thyroid tumors.
Results
We identified 262 and 352 hypermethylated and 13 and 21 hypomethylated genes in differentiated papillary and follicular tumors, respectively. Interestingly, the other tumor types analyzed displayed more hypomethylated genes (280 in anaplastic and 393 in medullary tumors) than aberrantly hypermethylated genes (86 in anaplastic and 131 in medullary tumors). Among the genes indentified, we show that 4 potential tumor suppressor genes (ADAMTS8, HOXB4, ZIC1, and KISS1R) and 4 potential oncogenes (INSL4, DPPA2 …
学术搜索中的文章
S Rodríguez-Rodero, AF Fernández… - The Journal of Clinical Endocrinology & Metabolism, 2013
