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Post‐transplantation cardiac xenograft growth in an orthotopic pig to baboon model is a life‐limiting phenomenon that is poorly understood. Possible causes of growth include both intrinsic and extrinsic etiologies. Extrinsic causes are thought to be attributed to maladaptive hypertrophy as a result of increased mean arterial pressure experienced by the cardiac xenograft after transplantation. Intrinsic causes are thought to be a result of discordant growth between pig xenografts and recipients. This results in intrinsic xenograft growth that parallels the donor and continues in a recipient in which growth is relatively minimal, controlled in part by the growth hormone receptor, IGF‐1 axis. Recently, Zaman, et al. published a study titled, “Selective loss of resident macrophage‐derived insulin‐like growth factor‐1 abolishes adaptive cardiac growth to stress,” in Immunity, Volume 54; Issue 9, pp. 2057–2071. They demonstrated …