作者
Linda W Chan, Marsha A Moses, Elizabeth Goley, Mary Sproull, Thierry Muanza, C Norman Coleman, William D Figg, Paul S Albert, Cynthia Ménard, Kevin Camphausen
发表日期
2004/2/1
期刊
Journal of clinical oncology
卷号
22
期号
3
页码范围
499-506
出版商
American Society of Clinical Oncology
简介
Purpose
To determine the predictive value of urinary levels of two angiogenic factors, vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMPs), in a longitudinal study to determine their correlation with 1-year progression-free survival in patients with cancer.
Patients and Methods
VEGF and MMP levels were measured in the urine of 65 cancer patients at first evaluation, during therapy, and at follow-up (n = 242); normalized by creatinine levels; and compared with 16 healthy controls. The correlation of initial levels and trends of VEGF and MMPs with 1-year progression-free survival was assessed using two-sample tests and stepwise logistic regression.
Results
Urinary VEGF levels at presentation were different between patients with local-regional cancer and normal controls, and between patients with metastatic prostate cancer and local-regional …
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LW Chan, MA Moses, E Goley, M Sproull, T Muanza… - Journal of clinical oncology, 2004