作者
T Mertens, A Handmandlu, A Hernandez, SD Collum, NY Chen, M Blackburn, H Karmouty-Quintana
发表日期
2017
期刊
American Journal of Respiratory and Critical Care Medicine
卷号
195
出版商
American Thoracic Society
简介
Background: Pulmonary hypertension (PH) is a devastating and progressive disease characterized by excessive proliferation and remodeling of pulmonary artery smooth muscle cells (PASMC) of the lung. Results: TAGLNcre mice showed increased hallmarks of PH including elevated right ventricle systolic pressure (RVSP), increased vascular smooth muscle deposition and an increased Fulton index, following exposure to BLM or HX-SU compared to controls (PBS or normoxia exposure).
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T Mertens, A Handmandlu, A Hernandez, SD Collum… - American Journal of Respiratory and Critical Care …, 2017