查看文章

Pulmonary hypertension (PH) is a disorder of the pulmonary vasculature defined by increased mean pulmonary arterial pressure (mPAP) leading to right ventricle hypertrophy and right-sided heart failure. PH is a common complication in idiopathic pulmonary fibrosis (IPF) where it is strongly associated with increased mortality. The pathologic process in PH is characterized by extensive vascular remodeling, leading to vessel narrowing and increased vascular tone. Adenosine is a signaling nucleoside that has been identified to contribute to both inflammatory and remodeling processes in the lung. Adenosine is produced following cellular stress or injury, such as hypoxia through the enzymes CD39 and CD73, and is degraded by adenosine deaminase (ADA), and signals by activating cell surface receptors (ADORA1, ADORA2A, ADORA2B and ADORA3). Increased levels of adenosine and the cell surface receptor …