作者
Yasser Sakr, Manuela Giovini, Marc Leone, Giacinto Pizzilli, Andreas Kortgen, Michael Bauer, Tommaso Tonetti, Gary Duclos, Laurent Zieleskiewicz, Samuel Buschbeck, V Marco Ranieri, Elio Antonucci
发表日期
2020/12
来源
Annals of intensive care
卷号
10
页码范围
1-13
出版商
Springer International Publishing
简介
Background
Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).
Main text
We review the current data on the epidemiology, the possible underlying pathophysiologic mechanisms, and the therapeutic implications of PE in relation to COVID-19. The incidence of PE is reported to be around 2.6–8.9% of COVID-19 in hospitalized patients and up to one-third of those requiring intensive care unit (ICU) admission, despite standard prophylactic anticoagulation. This may be explained by direct and indirect pathologic consequences of COVID-19, complement activation, cytokine release, endothelial dysfunction, and interactions between different types of blood cells.
Conclusion
Thromboprophylaxis should be started in all patients with suspected or confirmed COVID-19 admitted to the hospital. The …
学术搜索中的文章
Y Sakr, M Giovini, M Leone, G Pizzilli, A Kortgen… - Annals of intensive care, 2020