作者
Domenico Luca Grieco, Luca S Menga, Melania Cesarano, Tommaso Rosà, Savino Spadaro, Maria Maddalena Bitondo, Jonathan Montomoli, Giulia Falò, Tommaso Tonetti, Salvatore L Cutuli, Gabriele Pintaudi, Eloisa S Tanzarella, Edoardo Piervincenzi, Filippo Bongiovanni, Antonio M Dell’Anna, Luca Delle Cese, Cecilia Berardi, Simone Carelli, Maria Grazia Bocci, Luca Montini, Giuseppe Bello, Daniele Natalini, Gennaro De Pascale, Matteo Velardo, Carlo Alberto Volta, V Marco Ranieri, Giorgio Conti, Salvatore Maurizio Maggiore, Massimo Antonelli, Gian Marco Anzellotti, Laura Cascarano, Francesca Ceccaroni, Paolo De Santis, Mariangela Di Muro, Miriana Durante, Nicoletta Filetici, Veronica Gennenzi, Antonio Gullì, Gianmarco Lombardi, Alessio Maccaglia, Riccardo Maviglia, Alessandro Mele, Giovanna Mercurio, Teresa Michi, Tony C Morena, Martina Murdolo, Mariano Alberto Pennisi, Stefania Postorino, Antonella Potalivo, Francesca Pozzana, Carlotta Rubino, Martina Savino, Roberta Scarascia, Angela Scavone, Donatella Settanni, Serena Silva, Flavia Torrini, Joel Vargas, Carmelina Zaccone, COVID-ICU Gemelli Study Group
发表日期
2021/5/4
期刊
Jama
卷号
325
期号
17
页码范围
1731-1743
出版商
American Medical Association
简介
Importance
High-flow nasal oxygen is recommended as initial treatment for acute hypoxemic respiratory failure and is widely applied in patients with COVID-19.
Objective
To assess whether helmet noninvasive ventilation can increase the days free of respiratory support in patients with COVID-19 compared with high-flow nasal oxygen alone.
Design, Setting, and Participants
Multicenter randomized clinical trial in 4 intensive care units (ICUs) in Italy between October and December 2020, end of follow-up February 11, 2021, including 109 patients with COVID-19 and moderate to severe hypoxemic respiratory failure (ratio of partial pressure of arterial oxygen to fraction of inspired oxygen ≤200).
Interventions
Participants were randomly assigned to receive continuous treatment with helmet noninvasive ventilation (positive end-expiratory pressure, 10-12 cm H2O; pressure support, 10-12 cm H2O) for at least 48 hours …
学术搜索中的文章
DL Grieco, LS Menga, M Cesarano, T Rosà, S Spadaro… - Jama, 2021