作者
Shinichi Yachida, Efsevia Vakiani, Catherine M White, Yi Zhong, Tyler Saunders, Richard Morgan, Roeland F De Wilde, Anirban Maitra, Jessica Hicks, Angelo M DeMarzo, Chanjuan Shi, Rajni Sharma, Daniel Laheru, Barish H Edil, Christopher L Wolfgang, Richard D Schulick, Ralph H Hruban, Laura H Tang, David S Klimstra, Christine A Iacobuzio-Donahue
发表日期
2012/2/1
期刊
The American journal of surgical pathology
卷号
36
期号
2
页码范围
173-184
出版商
LWW
简介
Poorly differentiated neuroendocrine carcinomas (NECs) of the pancreas are rare malignant neoplasms with a poor prognosis. The aim of this study was to determine the clinicopathologic and genetic features of poorly differentiated NECs and compare them with other types of pancreatic neoplasms. We investigated alterations of KRAS, CDKN2A/p16, TP53, SMAD4/DPC4, DAXX, ATRX, PTEN, Bcl2, and RB1 by immunohistochemistry and/or targeted exomic sequencing in surgically resected specimens of 9 small cell NECs, 10 large cell NECs, and 11 well-differentiated neuroendocrine tumors (PanNETs) of the pancreas. Abnormal immunolabeling patterns of p53 and Rb were frequent (p53, 18 of 19, 95%; Rb, 14 of 19, 74%) in both small cell and large cell NECs, whereas Smad4/Dpc4, DAXX, and ATRX labeling was intact in virtually all of these same carcinomas. Abnormal immunolabeling of p53 and Rb proteins …
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S Yachida, E Vakiani, CM White, Y Zhong, T Saunders… - The American journal of surgical pathology, 2012