作者
William G Nelson, Angelo M De Marzo, THEODORE L DeWEESE, William B Isaacs
发表日期
2004/11/1
来源
The Journal of urology
卷号
172
期号
5
页码范围
S6-S12
出版商
No longer published by Elsevier
简介
PURPOSE
A new hypothesis for the etiology of prostate cancer is that chronic or recurrent prostate inflammation may initiate and promote prostate cancer development.
MATERIALS AND METHODS
We reviewed the current direct and indirect evidence from epidemiology, genetics, molecular biology and histopathology implicating inflammation in the pathogenesis of prostate cancer.
RESULTS
The case for prostate inflammation as a cause of prostate cancer is compelling. Epidemiology data have correlated prostatitis and sexually transmitted infections with increased prostate cancer risk and intake of anti-inflammatory drugs and antioxidants with decreased prostate cancer risk. Genetic studies have identified RNASEL, encoding an interferon inducible ribonuclease, and MSR1, encoding subunits of the macrophage scavenger receptor, as candidate inherited susceptibility genes for familial prostate cancer. Somatic …
引用总数
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WG Nelson, AM De Marzo, TL DeWEESE, WB Isaacs - The Journal of urology, 2004