作者
Joyce BJ Van Meurs, Thomas A Trikalinos, Stuart H Ralston, Susana Balcells, Maria Luisa Brandi, Kim Brixen, Douglas P Kiel, Bente L Langdahl, Paul Lips, Östen Ljunggren, Roman Lorenc, Barbara Obermayer-Pietsch, Claes Ohlsson, Ulrika Pettersson, David M Reid, Francois Rousseau, Serena Scollen, Wim Van Hul, Lidia Agueda, Kristina Åkesson, Lidia I Benevolenskaya, Serge L Ferrari, Göran Hallmans, Albert Hofman, Lise Bjerre Husted, Marcin Kruk, Stephen Kaptoge, David Karasik, Magnus K Karlsson, Mattias Lorentzon, Laura Masi, Fiona EA McGuigan, Dan Mellström, Leif Mosekilde, Xavier Nogues, Huibert AP Pols, Jonathan Reeve, Wilfried Renner, Fernando Rivadeneira, Natasja M Van Schoor, Kurt Weber, John PA Ioannidis, André G Uitterlinden
发表日期
2008/3/19
期刊
Jama
卷号
299
期号
11
页码范围
1277-1290
出版商
American Medical Association
简介
Context
Mutations in the low-density lipoprotein receptor–related protein 5 (LRP5) gene cause rare syndromes characterized by altered bone mineral density (BMD). More common LRP5 variants may affect osteoporosis risk in the general population.
Objective
To generate large-scale evidence on whether 2 common variants of LRP5 (Val667Met, Ala1330Val) and 1 variant of LRP6 (Ile1062Val) are associated with BMD and fracture risk.
Design and Setting
Prospective, multicenter, collaborative study of individual-level data on 37 534 individuals from 18 participating teams in Europe and North America. Data were collected between September 2004 and January 2007; analysis of the collected data was performed between February and May 2007. Bone mineral density was assessed by dual-energy x-ray absorptiometry. Fractures were identified via questionnaire, medical records, or radiographic documentation …
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JBJ Van Meurs, TA Trikalinos, SH Ralston, S Balcells… - Jama, 2008