作者
Emin Kansu, David Ward, Amber P Sanchez, Robyn Cunard, Mutlu Hayran, Beril Huseyin, Majella Vaughan, Grace Ku, Peter Curtin, Carolyn Mulroney, Caitlin Costello, Januario E Castro, Matthew Wieduwilt, Sue Corringham, Anita Ihasz-Davis, Connie Nelson, Edward D Ball
发表日期
2022/12/31
期刊
Hematology
卷号
27
期号
1
页码范围
785-794
出版商
Taylor & Francis
简介
Objectives
Chronic graft versus host disease (chronic GVHD) still remains the leading cause of late morbidity and mortality for allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients. In this retrospective study, 53 consecutive allo-HSCT patients with chronic GVHD refractory to corticosteroids were treated with extracorporeal photopheresis (ECP).
Methods
This study was performed as a retrospective single-center study. Medical records of a total of 59 patients treated with ECP for chronic GVHD were reviewed.
Results
Best organ responses to ECP were observed in skin, mouth mucosa, eyes and liver. Overall response rate (ORR) to ECP was 81.2% (CR 17% and PR 64.2%). Overall survival (OS) was 84.9% and 36.7%, at 1 and 3 years, respectively. Female sex appears to have an advantage on ORR. Patients achieving ORR were able to maintain their responses with a prolonged continuation of …
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E Kansu, D Ward, AP Sanchez, R Cunard, M Hayran… - Hematology, 2022