查看文章

Background

The frequency of simultaneous liver kidney (SLK) transplantation is increasing. Data are scanty on outcomes of SLK transplants for liver disease etiology.

Methods

Outcomes for liver and kidney grafts and patients survival at 5 years were compared for liver disease etiology among adults receiving SLK during 2002 and 2011 in the United States. Cox regression analysis models were built to determine the independent impact of liver disease etiology on outcomes.

Results

A total of 2,606 patients (mean age 53 years, 69% males, 55% Caucasians) received SLK for primary biliary cirrhosis (PBC, n= 76), primary sclerosing cholangitis (n= 81), hepatitis C virus (HCV)(n= 945), alcoholic liver disease (n= 495), alcohol and HCV (n= 152), cryptogenic cirrhosis (CC, n= 289), nonalcoholic steatohepatitis (NASH)(n= 221), hepatitis B virus (HBV)(n= 98), and hepatocellular carcinoma (HCC)(n= 249). HCV and NASH …