查看文章

We read with great interest the recent article by Katayama et al. 1 on the efficacy of erlotinib for intracranial metastases in patients who had shown a good response to gefitinib. Even if a substantial response is obtained with erlotinib as a readministration of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), the progression-free interval is usually not long enough. We present herein a patient with multiple brain metastases whose lesions were refractory to previous standard-dose EGFR-TKI therapies and whole brain radiotherapy (WBRT). Nevertheless, her brain metastases showed a remarkable response to “high-dose” erlotinib therapy.

A 52-year-old woman without a history of smoking presented with productive cough and progressive dyspnea. The computed tomography scan revealed bilateral pleural effusion, bilateral innumerable intrapulmonary nodules, and pericardial effusion. Multiple …