作者
Tadashi Sato, Kuniaki Seyama, Yasunori Sato, Hiroaki Mori, Sanae Souma, Taeko Akiyoshi, Yuzo Kodama, Takanori Mori, Sataro Goto, Kazuhisa Takahashi, Yoshinosuke Fukuchi, Naoki Maruyama, Akihito Ishigami
发表日期
2006/9/1
期刊
American journal of respiratory and critical care medicine
卷号
174
期号
5
页码范围
530-537
出版商
American Thoracic Society
简介
Rationale: Senescence marker protein-30 (SMP30) is a multifunctional protein providing protection to cellular functions from age-associated deterioration. We previously reported that SMP30 knockout (SMP30Y/−) mice are capable of being novel models for senile lung with age-related airspace enlargement and enhanced susceptibility to harmful stimuli.
Objectives: Aging and smoking are considered as major contributing factors for the development of pulmonary emphysema. We evaluated whether SMP30Y/− mice are susceptible to oxidative stress associated with aging and smoking.
Methods: Age-related changes of protein carbonyls in lung tissues from the wild-type (SMP30Y/+) and SMP30Y/− mice were evaluated. Both strains were exposed to cigarette smoke for 8 wk. Histopathologic and morphologic evaluations of the lungs, protein carbonyls and malondialdehyde in the lung tissues, total glutathione content …
引用总数
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T Sato, K Seyama, Y Sato, H Mori, S Souma, T Akiyoshi… - American journal of respiratory and critical care …, 2006