作者
Sivaranjani Namasivayam, Mamoudou Maiga, Wuxing Yuan, Vishal Thovarai, Diego L Costa, Lara R Mittereder, Matthew F Wipperman, Michael S Glickman, Amiran Dzutsev, Giorgio Trinchieri, Alan Sher
发表日期
2017/12
期刊
Microbiome
卷号
5
页码范围
1-17
出版商
BioMed Central
简介
Background
Effective treatment of Mycobacterium tuberculosis (Mtb) infection requires at least 6 months of daily therapy with multiple orally administered antibiotics. Although this drug regimen is administered annually to millions worldwide, the impact of such intensive antimicrobial treatment on the host microbiome has never been formally investigated. Here, we characterized the longitudinal outcome of conventional isoniazid-rifampin-pyrazinamide (HRZ) TB drug administration on the diversity and composition of the intestinal microbiota in Mtb-infected mice by means of 16S rRNA sequencing. We also investigated the effects of each of the individual antibiotics alone and in different combinations.
Results
While inducing only a transient decrease in microbial diversity, HRZ treatment triggered a marked, immediate and reproducible alteration in community …
学术搜索中的文章
S Namasivayam, M Maiga, W Yuan, V Thovarai… - Microbiome, 2017