作者
Xiaozhou Zhang, Timothy C Borbet, Angela Fallegger, Matthew F Wipperman, Martin J Blaser, Anne Müller
发表日期
2021/2/23
期刊
Mbio
卷号
12
期号
1
页码范围
10.1128/mbio. 03335-20
出版商
American Society for Microbiology
简介
Antibiotic exposure early in life and other practices impacting the vertical transmission and ordered assembly of a diverse and balanced gut microbiota are associated with a higher risk of immunological and metabolic disorders such as asthma and allergy, autoimmunity, obesity, and susceptibility to opportunistic infections. In this study, we used a model of perinatal exposure to the broad-spectrum antibiotic ampicillin to examine how the acquisition of a dysbiotic microbiota affects neonatal immune system development. We found that the resultant dysbiosis imprints in a manner that is irreversible after weaning, leading to specific and selective alteration of the colonic CD4+ T-cell compartment. In contrast, colonic granulocyte and myeloid lineages and other mucosal T-cell compartments are unaffected. Among colonic CD4+ T cells, we observed the most pronounced effects on neuropilin-negative, RORγt- and Foxp3 …
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X Zhang, TC Borbet, A Fallegger, MF Wipperman… - Mbio, 2021